Discovery of a Highly Potent Anti-inflammatory Epoxyisoprostane-Derived Lactone
- 4 December 2014
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 136 (50) , 17382-17385
Abstract
Epoxyisoprostanes EI (1) and EC (2) are effective inhibitors of the secretion of proinflammatory cytokines IL-6 and IL-12. In detailed studies toward the investigation of the molecular mode of action of these structures, a highly potent lactone (3) derived from 1 was identified. The known isoprostanoids 1 and 2 are most likely precursors of 3, the product of facile intramolecular reaction between the epoxide with the carboxylic acid in 2.Keywords
Funding Information
- Eidgenössische Technische Hochschule Zürich (ETH-18 09-1)
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