The sodium pumping NADH:quinone oxidoreductase (Na+-NQR), a unique redox-driven ion pump
- 23 July 2014
- journal article
- review article
- Published by Springer Nature in Journal of Bioenergetics and Biomembranes
- Vol. 46 (4) , 289-298
Abstract
The Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) is a unique Na+ pumping respiratory complex found only in prokaryotes, that plays a key role in the metabolism of marine and pathogenic bacteria, including Vibrio cholerae and other human pathogens. Na+-NQR is the main entrance for reducing equivalents into the respiratory chain of these bacteria, catalyzing the oxidation of NADH and the reduction of quinone, the free energy of this redox reaction drives the selective translocation of Na+ across the cell membrane, which energizes key cellular processes. In this review we summarize the unique properties of Na+-NQR in terms of its redox cofactor composition, electron transfer reactions and a possible mechanism of coupling and pumping.Keywords
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