Major Bioactive Alkaloids and Biological Activities of Tabernaemontana Species (Apocynaceae)
Open Access
Abstract
Several species belonging to the genus Tabernaemontana have been well researched and utilized for their wide-ranging biological activities. A few of the most prominent species include Tabernaemontana divaricata, Tabernaemontana catharinensis, Tabernaemontana crassa, and Tabernaemontana elegans. These species and many others within the genus often display pharmacological importance, which is habitually related to their chemical constituents. The secondary metabolites within the genus have demonstrated huge medicinal potential for the treatment of infections, pain, injuries, and various diseases. Regardless of the indispensable reports and properties displayed by Tabernaemontana spp., there remains a wide variety of plants that are yet to be considered or examined. Thus, an additional inclusive study on species within this genus is essential. The current review aimed to extensively analyze, collate, and describe an updated report of the current literature related to the major alkaloidal components and biological activities of species within the genus Tabernaemontana.Keywords
Funding Information
- Deanship of Scientific Research, King Saud University (RG-1440-024)
This publication has 214 references indexed in Scilit:
- In vitro antibacterial activity of Tabernaemontana alternifolia (Roxb) stem bark aqueous extracts against clinical isolates of methicillin resistant Staphylococcus aureusAnnals of Clinical Microbiology and Antimicrobials, 2013
- Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cellsJournal of Ethnopharmacology, 2013
- Cytotoxic Indole Alkaloids from Tabernaemontana divaricataJournal of Natural Products, 2013
- Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2)Genetics and Molecular Biology, 2013
- Chemical Constituents Antioxidant and Anticholinesterasic Activity of Tabernaemontana catharinensisThe Scientific World Journal, 2013
- Anticancer drug discovery in the future: an evolutionary perspectiveDrug Discovery Today, 2009
- Induction of apoptosis in HuH-7 cancer cells by monoterpene and β-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegansBioorganic & Medicinal Chemistry Letters, 2009
- Conophylline: A novel differentiation inducer for pancreatic β cellsThe International Journal of Biochemistry & Cell Biology, 2006
- 19-Epivoacristine, an Iboga Alkaloid Isolated from Peschiera affinisJournal of the Brazilian Chemical Society, 1996
- Analgesic Components from Bornean Medicinal Plants, Tabernaemontana pauciflora BLUME and Tabernaemontana pandacaqui POIR.Chemical and Pharmaceutical Bulletin, 1992