Prostaglandin-like Activity in Ocular Inflammation

Authors:
  • KEK. E. Eakins
    K. E. Eakins
  • RWR. A. F. Whitelocke
    R. A. F. Whitelocke
  • ABA. Bennett
    A. Bennett
  • AMA. C. Martenet
    A. C. Martenet
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Abstract
Aqueous humour samples from untreated patients with acute anterior uveitis were found to contain substantial amounts of prostaglandin-like activity. Little activity was found in aqueous from patients treated with steroids, and none (<2 ng/ml) was detected in aqueous from the uninflamed eyes of patients with cataract. Alkaline hydrolysis of the samples from inflamed eyes suggested the presence of both E and F prostaglandin-like activity. These results show that prostaglandins may be involved in acute anterior uveitis.

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