The vitamin D3 hormone, 1,25(OH)2D3, regulates fibroblast growth factor 23 (FGF23) production in human skin cells
Authors:
- Franz EwendtFEFranz Ewendt
- Zorica JanjetovicZorica Janjetovic
- Tae-Kang KimTae-Kang Kim
- Alisa A. MobleyAMAlisa A. Mobley
- Anna A. BrożynaABAnna A. Brożyna
- Senthilkumar RavichandranSRSenthilkumar Ravichandran
- Adrian FabisiakAFAdrian Fabisiak
- Pawel BrzeminskiPBPawel Brzeminski
- Rafal R. SicinskiRafal R. Sicinski
- Gabriele I. StanglGSGabriele I. Stangl
- Robert C. TuckeyRTRobert C. Tuckey
- Andrzej T. SlominskiASAndrzej T. Slominski
- 1 April 2025
- journal article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 328 (4) , C1177-C1192
Abstract
This study shows for the first time the expression and secretion of the FGF23 hormone by human skin cells. In addition, we identified the active vitamin D3 hormone, 1,25(OH)2D3, to be a potent regulator of dermal FGF23 expression and protein secretion, partly involving the vitamin D receptor. Furthermore, we provide initial evidence demonstrating that FGF23 upregulates the gene expression of CYP11A1 and CYP27A1 in keratinocytes.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (522549509)
- HHS | National Institutes of Health (1R01AR073004)
- HHS | National Institutes of Health (R01AR071189)
- HHS | National Institutes of Health (R21AI149267)
- U.S. Department of Veterans Affairs (1I01BX004293)
- U.S. Department of Veterans Affairs (2I01BX004293)
- U.S. Department of War (#W81XWH2210689)
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