(±) Cochlearoids N–P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities
- 9 July 2018
- journal article
- research article
- Published by Taylor & Francis in Journal of Asian Natural Products Research
- Vol. 21 (6) , 542-550
Abstract
Three pairs of meroterpenoids (±) cochlearoids N–P (1–3) were isolated from the fruiting bodies of Ganoderma cochlear. Their structures including absolute configurations were assigned by spectroscopic techniques. All the isolated compounds were tested for their inhibitory activities toward BRD4, human cancer cells, and micro-organisms. The results show that the enantiomers of (±)-1 are BRD4 inhibitors, (−)-1 and (+)-3 are cytotoxic against human cancer cells (K562) with IC50 values of 7.68 and 6.68 μM, respectively. Besides compounds (±)-2 and (±)-3 exhibit potent inhibitory activity against Staphylococcus aureus with IC50 values in the range of 5.43–17.99 μM.Keywords
Funding Information
- National Natural Science Foundation of China (21472199)
- National Key Research and Development Program of China (2017YFA0503900)
- National Science Fund for Distinguished Young Scholars (81525026)
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