Ruthenium-Catalyzed Asymmetric trans-Selective Hydrogenation of 2,3-Disubstituted Quinoxaline Derivatives

Authors:
Publisher website
Google Scholar
Abstract
The asymmetric trans-selective hydrogenation of arenes has long been a significant challenge. In this work, we were able to control the trans/cis selectivity in ruthenium-catalyzed asymmetric hydrogenation of 2,3-disubstituted quinoxalines by varying the catalyst counteranion. Using density functional theory calculations, we investigated the weak interactions─such as CH/π and hydrogen bonding─among the counteranion, the catalyst framework, and the substrate, elucidating the fundamental influence of counteranions on trans/cis selectivity in the asymmetric hydrogenation of quinoxalines.
Funding Information
  • National Key Research and Development Program of China (2021YFA1500200)
  • National Natural Science Foundation of China (22471278, 92256303)

This publication has 53 references indexed in Scilit: