3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogs of lovastatin

Authors:
  • WHW. J. Holtz
    W. J. Holtz
  • RSR. L. Smith
    R. L. Smith
  • AAA. W. Alberts
    A. W. Alberts
  • JGJ. L. Gilfillan
    J. L. Gilfillan
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Abstract
A general route for preparing side chain ether analogues of lovastatin is presented. These analogues proved to be weaker inhibitors of HMG-CoA reductase than the corresponding side chain ester analogues. Interestingly, inhibitory potency was enhanced markedly when the 4-fluoro group was incorporated in the aromatic moiety of the side chain benzyl group of 2d.