Tin Protoporphyrin Inhibits Carbon Monoxide Production in Suckling Mice
Authors:
- David K. StevensonDSDavid K. Stevenson
- Elizabeth M. WatsonEWElizabeth M. Watson
- Susan R. HintzSHSusan R. Hintz
- Charles B. KimCKCharles B. Kim
- Hendrik J. VremanHVHendrik J. Vreman
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 51 (1) , 40-44
Abstract
The carbon monoxide excretion rate (VeCO) of groups of 1-day-old mice was measured after administration of two separate doses of 50 nmol of tin protoporphyrin (TP) per gram of body weight. The mean VeCO of the saline-treated control groups over the study period was 1.50 ± 0.26 nmol/g/h, and that of the TP-treated groups was 1.35 ± 0.29 nmol/g/h. Tin protoporphyrin treatment reduced the CO excretion by approximately 14% in 2-day-old mice over 24–48 h.Keywords
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