Abstract
I started in psychiatry at the Maudsley Hospital and Institute of Psychiatry, London, in October 1972, and spent the next 3 years completing my basic training. I was then offered a research post studying the excretion of dimethyltryptamine (DMT) in patients with schizophrenia. DMT is a hallucinogen used by Amazonian Indians in their religious ceremonies, as well as a minor street drug, and the idea was that people with schizophrenia might be walking hallucinogenic factories. At the time, this idea, which appears bizarre in retrospect, was the main neurochemical alternative to the dopamine hypothesis.1