Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)
Authors:
- Trevor M. PenningTPTrevor M. Penning
- Joseph M. JezJJJoseph M. Jez
- Hseuh-Kung LinHLHseuh-Kung Lin
- Haiching MaHMHaiching Ma
- Kapila RatnamKRKapila Ratnam
- 1 January 2001
- journal article
- research article
- Published by Elsevier in Molecular and Cellular Endocrinology
- Vol. 171 (1-2) , 137-149
Abstract
No abstract availableKeywords
This publication has 29 references indexed in Scilit:
- Localization of Type 5 17 -Hydroxysteroid Dehydrogenase, 3 -Hydroxysteroid Dehydrogenase, and Androgen Receptor in the Human Prostate by in Situ Hybridization and ImmunocytochemistryEndocrinology, 1999
- Characteristics of a Highly Labile Human Type 5 17 -Hydroxysteroid DehydrogenaseEndocrinology, 1999
- Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione,Biochemistry, 1998
- Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3α-hydroxysteroid/dihydrodiol dehydrogenaseStructure, 1997
- Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cellsBiochemical Journal, 1996
- Structure of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Complexed with NADP+Biochemistry, 1996
- 17β-Hydroxysteroid dehydrogenase: isozymes and mutationsJournal of Endocrinology, 1995
- Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.Proceedings of the National Academy of Sciences, 1994
- The kinetic mechanism catalysed by homogeneous rat liver 3α-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugsBiochemical Journal, 1991
- Detection of a transient enzyme-steroid complex during active-site-directed irreversible inhibition of 3-oxo-.DELTA.5-steroid isomeraseBiochemistry, 1986