Celiac disease: Alternatives to a gluten free diet
Open Access
- 1 January 2010
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastrointestinal Pharmacology and Therapeutics
- Vol. 1 (1) , 36-9
Abstract
Celiac disease is a chronic inflammatory disorder of the small intestine caused by the ingestion of gluten or related rye and barley proteins. At present, the only available treatment is a strict gluten-exclusion diet. However, recent understanding of the molecular basis for this disorder has improved and enabled the identification of targets for new therapies. This article aims to critically summarize these recent studies.Keywords
This publication has 28 references indexed in Scilit:
- Higher constitutive IL15Rα expression and lower IL-15 response threshold in coeliac disease patientsClinical and Experimental Immunology, 2008
- Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3Gastroenterology, 2008
- A Non-Human Primate Model for Gluten SensitivityPLOS ONE, 2008
- Structure-based design of α-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2Bioorganic & Medicinal Chemistry, 2007
- The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT‐1001 in coeliac disease subjects: a proof of concept studyAlimentary Pharmacology & Therapeutics, 2007
- Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac diseaseGut, 2007
- Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac diseaseGut, 2005
- Future therapeutic options for celiac diseaseNature Clinical Practice Gastroenterology & Hepatology, 2005
- Structural Basis for Gluten Intolerance in Celiac SprueScience, 2002
- Innate immunity: impact on the adaptive immune responseCurrent Opinion in Immunology, 1997