Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and N^α-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis

This publication has 9 references indexed in Scilit:

• Elucidation of the Mechanism of Endo-Xaa^C-terminal Peptide Impurity Formation in SPPS through DoE Investigation, Their Control, and Suppression
  Organic Process Research & Development, 2021
• Synthesis and application of N^α‐Fmoc‐N^π‐4‐methoxybenzyloxymethylhistidine in solid phase peptide synthesis
  Journal of Peptide Science, 2012
• 4-Methoxybenzyloxymethyl group as an Nπ-protecting group for histidine to eliminate side-chain-induced racemization in the Fmoc strategy
  Tetrahedron Letters, 2011
• Oxyma: An Efficient Additive for Peptide Synthesis to Replace the Benzotriazole‐Based HOBt and HOAt with a Lower Risk of Explosion^[1]
  Chemistry – A European Journal, 2009
• 3-(Diethoxyphosphoryloxy)-1,2,3- benzotriazin-4(3H)-one (DEPBT): A New Coupling Reagent with Remarkable Resistance to Racemization
  Organic Letters, 1999
• Protection of histidine in peptide synthesis: A Reassessment of the trityl group
  Tetrahedron Letters, 1987
• MECHANISM OF RACEMISATION OF HISTIDINE DERIVATIVES IN PEPTIDE SYNTHESIS
  International Journal of Peptide and Protein Research, 1980
• Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolen
  European Journal of Inorganic Chemistry, 1970
• Mechanistic studies of peptide oxazolone racemization
  Tetrahedron, 1967