A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Vibrio cholerae , the causative agent of the diarrheal disease cholera, benefits from a sessile biofilm lifestyle that enhances survival outside the host but also contributes to host colonization and infectivity. The bacterial second messenger c-di-GMP has been identified as a central regulator of biofilm formation, including in V. cholerae ; however, our understanding of the pathways that contribute to this process is incomplete. Here, we define a conserved signaling system that controls the stability of large adhesion proteins at the cell surface of V. cholerae , which are important for cell attachment and biofilm formation. Insight into the regulatory circuit underlying biofilm formation may inform targeted strategies to interfere with a process that renders this bacterium remarkably adaptable to changing environments.
Funding Information
  • HHS | National Institutes of Health (R01GM123609)
  • HHS | National Institutes of Health (R01AI114261)
  • HHS | National Institutes of Health (P20-GM113132)
  • National Science Foundation (MCB 1817342)
  • Cystic Fibrosis Foundation (STANTO15RO)
  • Brown Foundation

This publication has 88 references indexed in Scilit: