Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Pancreatic Cancer

Authors:
  • NLNa Li
    Na Li
  • WZWeiwei Zhao
    Weiwei Zhao
  • JRJing Ren
    Jing Ren
  • MWMengqi Wei
    Mengqi Wei
  • YYYong Yang
    Yong Yang
  • YWYingmei Wang
    Yingmei Wang
  • XFXin Fu
    Xin Fu
  • ZZZhuoli Zhang
    Zhuoli Zhang
  • ALAndrew C. Larson
    Andrew C. Larson
  • YHYi Huan
    Yi Huan
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Abstract
To clarify diffusion and perfusion abnormalities and evaluate correlation between apparent diffusion coefficient (ADC), MR perfusion and histopathologic parameters of pancreatic cancer (PC). Eighteen patients with PC underwent diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Parameters of DCE-MRI and ADC of cancer and non-cancerous tissue were compared. Correlation between the rate constant that represents transfer of contrast agent from the arterial blood into the extravascular extracellular space (Ktrans), volume of the extravascular extracellular space per unit volume of tissue (Ve), and ADC of PC and histopathologic parameters were analyzed. The rate constant that represents transfer of contrast agent from the extravascular extracellular space into blood plasma, Ktrans, tissue volume fraction occupied by vascular space, and ADC of PC were significantly lower than nontumoral pancreases. Ve of PC was significantly higher than that of nontumoral pancreas. Apparent diffusion coefficient and Ktrans values of PC were negatively correlated to fibrosis content and fibroblast activation protein staining score. Fibrosis content was positively correlated to Ve. Apparent diffusion coefficient values and parameters of DCE-MRI can differentiate PC from nontumoral pancreases. There are correlations between ADC, Ktrans, Ve, and fibrosis content of PC. Fibroblast activation protein staining score of PC is negatively correlated to ADC and Ktrans. Apparent diffusion coefficient, Ktrans, and Ve may be feasible to predict prognosis of PC.

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