Multicentre post-infarction trial of propranolol in 49 hospitals in the United Kingdom, Italy, and Yugoslavia.
Authors:
- N S BaberNBN S Baber
- D W EvansDED W Evans
- G HowittGHG Howitt
- M ThomasMTM Thomas
- T WilsonTWT Wilson
- J A LewisJLJ A Lewis
- P M DawesPDP M Dawes
- K HandlerKHK Handler
- R TusonRTR Tuson
Abstract
A multicentre study of survivors of an anterior myocardial infarction is reported. The trial consisted of 720 patients and was a double-blind, placebo-controlled study with propranolol 40 mg three times a day. Trial entry was at two to 14 days (mean 8.5 days) and follow-up at one, three, and in most centres, six and nine months. The trial was designed to detect a 50 per cent reduction in mortality and this was not shown. The non-fatal reinfarction rate was similar in both groups. Subgroup analysis identified several prognostic risk factors for death, none of which interacted with treatment.Keywords
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