Hyperbaric oxygen improves ultraviolet B irradiation‐induced melanin pigmentation and diminishes senile spot size

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Abstract
Background: The effects of exposure to hyperbaric oxygen on ultraviolet B (UVB) irradiation‐induced melanin pigmentations of skins and on senile spot sizes of faces were investigated.Methods: In the first experiment, male subjects were irradiated with UVB on their upper arms for inducing erythema and the subsequent melanin pigmentation. They were exposed to a hyperbaric environment at 1.25 atmospheres absolute (ATA) with 32% oxygen for 1 h/day, three times per week. In the second experiment, female subjects were exposed to a hyperbaric environment at 1.25 ATA with 32% oxygen for 1 h/day, two times per week.Results: In the first experiment, melanin pigmentations lightened after 4 weeks of exposure to hyperbaric oxygen. In the second experiment, senile spot sizes became small after 12 weeks of exposure to hyperbaric oxygen.Conclusion: We concluded that exposure to hyperbaric oxygen used in this study accelerates both the fading in melanin pigmentation and the decrease in senile spot size.

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