Supplementary Figure S4 from Protein Kinase B (PKB/AKT) Protects IDH-Mutated Glioma from Ferroptosis via Nrf2

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Abstract
(A) Heatmap of gene expression profile for glioma specimen. The leading edge of the KEGG_MTOR_SIGNALING_PATHWAY geneset was shown. (B) Dose-response curve measured the cell viability in IDH1WT NHA cells in response to TMZ/Ipa combination treatment. (C) isobologram analysis showed the synergistic effect of TMZ and Ipa in IDH1WT NHA cells. (D) The combination index (C.I.) was calculated to show the additive effect of TMZ and Ipa.