Human embryonic and induced pluripotent stem cells in clinical trials: Table 1
Authors:
Open Access
- 17 November 2015
- journal article
- review article
- Published by Oxford University Press (OUP) in British Medical Bulletin
- Vol. 116 (1) , 19-27
Abstract
Human embryonic and induced pluripotent stem cells (hESC and hiPSC) have tremendous potential for clinical implementation. In spite of all hurdles and controversy, clinical trials in treatment of spinal cord injury, macular degeneration of retina, type 1 diabetes and heart failure are already ongoing. ClinicalTrials.gov database, International Clinical Trials Registry Platform, PubMed and press releases and websites of companies and institutions working on hESC- and iPSC-based cellular therapy. The initial results from multiple clinical trials demonstrate that hESC-based therapies are safe and promising. Are iPSC cells safe in the clinical application? Is there a room for both hESC and iPSC in the future clinical applications? Increasing number of new clinical trials. Development of hESC- and/or iPSC-based cellular therapy for other diseases.Keywords
This publication has 23 references indexed in Scilit:
- Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studiesThe Lancet, 2015
- Wrongful Termination: Lessons From the Geron Clinical TrialStem Cells Translational Medicine, 2014
- Embryonic stem cell trials for macular degeneration: a preliminary reportThe Lancet, 2012
- Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia PatientPLOS Medicine, 2009
- Induced Pluripotent Stem Cell Lines Derived from Human Somatic CellsScience, 2007
- Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell, 2007
- Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 2006
- Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord InjuryThe Journal of Neuroscience, 2005
- Derivation and Comparative Assessment of Retinal Pigment Epithelium from Human Embryonic Stem Cells Using TranscriptomicsCloning and Stem Cells, 2004
- Embryonic Stem Cell Lines Derived from Human BlastocystsScience, 1998