Identity‐By‐Descent Mapping Using Multi‐Individual IBD With Genome‐Wide Multiple Testing Adjustment
Open Access
- 28 July 2025
- journal article
- Published by Wiley in Genetic Epidemiology
- Vol. 49 (6) , e70015
Abstract
We present an identity‐by‐descent mapping approach to test the association between genome‐wide loci and complex traits. Our method evaluates whether levels of genetic similarities at specific genomic locations, captured by local relatedness matrices derived from multi‐individual IBD sharing, are associated with phenotypic variation in complex traits. In addition, we propose an approach to adjust for multiple testing in genome‐wide IBD mapping scans based on the correlation structure between test statistics across the genome. Through simulation studies, we demonstrate that our test has a well‐controlled genome‐wide type I error rate and superior power to detect rare and untyped variants compared to standard single‐variant tests. We applied our method to systolic blood pressure data from White British individuals in the UK Biobank.Keywords
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This publication has 60 references indexed in Scilit:
- Genome‐wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scoresGenetic Epidemiology, 2022
- Coalescent Simulation with msprime2020
- A tutorial on conducting genome‐wide association studies: Quality control and statistical analysisInternational Journal of Methods in Psychiatric Research, 2018
- Detecting Identity by Descent and Estimating Genotype Error Rates in Sequence DataThe American Journal of Human Genetics, 2013
- Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing StudiesThe American Journal of Human Genetics, 2012
- Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association TestThe American Journal of Human Genetics, 2011
- DASH: A Method for Identical-by-Descent Haplotype Mapping Uncovers Association with Recent VariationThe American Journal of Human Genetics, 2011
- Linkage analysis without defined pedigreesGenetic Epidemiology, 2011
- Efficient multilocus association testing for whole genome association studies using localized haplotype clusteringGenetic Epidemiology, 2007
- Multipoint oligogenic linkage analysis of quantitative traitsGenetic Epidemiology, 1997