A new antitumor antibiotic, stubomycin.
Authors:
- Iwao UmezawaIUIwao Umezawa
- Hideo TakeshimaHTHideo Takeshima
- Kanki KomiyamaKKKanki Komiyama
- Yoshie KohYKYoshie Koh
- Hiroshi YamamotoHYHiroshi Yamamoto
- Masae KawaguchiMKMasae Kawaguchi
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (3) , 259-265
Abstract
A new antibiotic, stubomycin, was isolated from the culture broth and mycelia of Streptomyces strain No. KG-2245. Stubomycin was prepared as colorless plates and has the empirical formula C29H35NO5. The antibiotic possesses growth inhibitory activity against Gram-positive bacteria and transplantable murine tumors, such as Ehrlich carcinoma, and leukemia P388. The antibiotic also shows direct cytotoxic activity against HeLa cells in vitro.Keywords
This publication has 1 reference indexed in Scilit:
- The Utilization of Carbon Compounds by Some Actinomycetales as an Aid for Species DeterminationJournal of Bacteriology, 1948