The Beneficial Role of Thiamine in Parkinson Disease

Authors:
Publisher website
Google Scholar
Abstract
Summary: Parkinson disease (PD) is the second most common form of neurodegeneration among elderly individuals.PDis clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. In this paper, we review the evidence for an association betweenPDand thiamine. Interestingly, a significant association has been demonstrated betweenPDand low levels of serum thiamine, and thiamine supplements appear to have beneficial clinical effects againstPD. Multiple studies have evaluated the connection between thiamine andPDpathology, and candidate pathways involve the transcription factorSp1, p53,Bcl‐2, caspase‐3, tyrosine hydroxylase, glycogen synthase kinase‐3β, vascular endothelial growth factor, advanced glycation end products, nuclear factor kappaB, mitogen‐activated protein kinase, and the reduced form of nicotinamide adenine dinucleotide phosphate. Thus, a review of the literature suggests that thiamine plays a role inPD, although further investigation into the effects of thiamine inPDis needed.

This publication has 135 references indexed in Scilit: