A real – life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough
Authors:
- Roxana K MinchevaRMRoxana K Mincheva
- Tanya Z KralimarkovaTKTanya Z Kralimarkova
- Miroslava RashevaMRMiroslava Rasheva
- Zlatko DimitrovZDZlatko Dimitrov
- Denislava NedevaDNDenislava Nedeva
- Maria StaevskaMSMaria Staevska
- Vera PapochievaVPVera Papochieva
- Penka PerenovskaPPPenka Perenovska
- Karina BachevaKBKarina Bacheva
- Vasil D DimitrovVDVasil D Dimitrov
- Todor A PopovTPTodor A Popov
Open Access
- 20 March 2014
- journal article
- Published by Springer Nature in Cough
- Vol. 10 (1) , 2
Abstract
Different conditions make the proximal airways susceptible to tussigenic stimuli in the chronic cough (CC) syndrome. Leukotrienes can be implicated in the inflammatory mechanism at play in it. Montelukast is a selective cysteinyl-leukotriene receptor antagonist with proven effectiveness in patients with asthma. The aim of our real-life pilot study was to use montelukast to relieve cough symptoms in patients with CC allegedly due to the two frequent causes other than asthma – upper airway cough syndrome and gastroesophageal reflux (GER).Keywords
This publication has 35 references indexed in Scilit:
- Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicinCough, 2012
- Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammationFree Radical Biology and Medicine, 2010
- Antitussive Effects of the Leukotriene Receptor Antagonist Montelukast in Patients with Cough Variant Asthma and Atopic CoughAllergology International, 2010
- LeukotrienesNew England Journal of Medicine, 2007
- Review Series: Chronic cough: Future directions in chronic cough: mechanisms and antitussivesChronic Respiratory Disease, 2007
- ERS guidelines on the assessment of coughEuropean Respiratory Journal, 2007
- Development and evaluation of FSSG: frequency scale for the symptoms of GERDJournal of Gastroenterology, 2004
- Effectiveness of montelukast in the treatment of cough variant asthmaAnnals of Allergy, Asthma & Immunology, 2004
- Platelet-activating factor—and leukotriene B4-induced release of lactoferrin from blood neutrophils of atopic and nonatopic individualsJournal of Allergy and Clinical Immunology, 1990
- CHRONIC COUGH: EOSINOPHILIC BRONCHITIS WITHOUT ASTHMAThe Lancet, 1989