Two New Pyridine Monoterpene Alkaloids by Chemical Conversion of a Commercial Extract of Harpagophytum procumbens
Authors:
- 18 December 1998
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (2) , 211-213
Abstract
The treatment of harpagide (1), harpagoside (2), or 8-O-p-coumaroylharpagide (3), the main iridoids of Harpagophytum procumbens and Harpagophytum zeyheri, with NH3 and HCl led to aucubinine B(4), a pyridine monoterpene alkaloid (PMTA). A similar procedure applied to a commercial extract of H. procumbens yielded 4 and two new PMTAs named beatrine A (5) and beatrine B (6). The structures of these new PMTAs were established using ESIMS and 2D NMR. Their semisynthesis was analyzed in terms of reaction mechanisms.Keywords
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