Influence of the Membrane Dye R18 and of DMSO on Cell Penetration of Guanidinium‐Rich Peptides

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Abstract
A quantitative analysis by confocal fluorescence microscopy of the entry into HEK293 and MCF‐7 cells by fluorescein‐labeled octaarginine (1) and by three octa‐Adp derivatives (2 – 4, octamers of the β‐Asp‐Arg‐dipeptide, derived from the biopolymer cyanophycin) is described, including the effects of the membrane dye R18 and of DMSO on cell penetration.
Funding Information
  • European Research Council (681587)

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