Novel IL27p28/IL12p40 Cytokine Suppressed Experimental Autoimmune Uveitis by Inhibiting Autoreactive Th1/Th17 Cells and Promoting Expansion of Regulatory T Cells
Authors:
- Ren-Xi WangRWRen-Xi Wang
- Cheng-Rong YuCYCheng-Rong Yu
- Rashid M. MahdiRMRashid M. Mahdi
- Charles E. EgwuaguCECharles E. Egwuagu
Open Access
- 1 October 2012
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 287 (43) , 36012-36021
Abstract
No abstract availableKeywords
This publication has 47 references indexed in Scilit:
- STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription FactorsJournal of Biological Chemistry, 2011
- Understanding Autoimmune Uveitis through Animal Models The Friedenwald LectureInvestigative Ophthalmology & Visual Science, 2011
- A role for IL-27p28 as an antagonist of gp130-mediated signalingNature Immunology, 2010
- A look at autoimmunity and inflammation in the eyeJournal of Clinical Investigation, 2010
- Differentiation of Effector CD4 T Cell PopulationsAnnual Review of Immunology, 2010
- Interleukin‐35: odd one out or part of the family?Immunological Reviews, 2008
- Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector categoryJournal of Experimental Medicine, 2008
- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cellsJournal of Experimental Medicine, 2008
- TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1Nature Medicine, 2007
- Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signalsJournal of Experimental Medicine, 2007