Plasma Cell Dyscrasia with Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes

Authors:
  • PBP. A. Bardwick
    P. A. Bardwick
  • NZN. J. Zvaifler
    N. J. Zvaifler
  • GGG. N. Gill
    G. N. Gill
  • DND. Newman
    D. Newman
  • GGG. D. Greenway
    G. D. Greenway
  • DRD. L. Resnick
    D. L. Resnick
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Abstract
Two patients with plasma cell dyscrasias, manifested by osteosclerotic bone lesions and small amounts of M protein, and a complicating multi-system disorder are described. Their features of severe sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, anasarca, elevated CSF protein, and skin hyperpigmentation are similar to a clinical syndrome reported primarily in Japanese men. Two previously unrecognized findings--hyperprolactinemia and an unusual radiographic abnormality of fluffy, spiculated bony proliferation--may facilitate recognition of the syndrome. The relationship of these various manifestations to the plasma cell dyscrasia is unknown, but a number of possibilities are discussed.