Influence of Polymer-Pore Interactions on Translocation
- 1 October 2007
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 99 (14) , 148102
Abstract
We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve the translocation probability. At the same time, it also increases the translocation time slowly for a weak attraction while an exponential dependence is observed for a strong attraction. For fixed driving force and chain length the histogram of translocation time has a transition from Gaussian distribution to long-tailed distribution with increasing attraction. Under a weak driving force and a strong attractive force, both the translocation time and the residence time in the pore show a nonmonotonic behavior as a function of the chain length. Our simulations results are in good agreement with recent experimental data.Keywords
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This publication has 28 references indexed in Scilit:
- Polymer translocation through a nanopore under a pulling forcePhysical Review E, 2007
- Single Polymer Molecules in a Protein Nanopore in the Limit of a Strong Polymer-Pore AttractionPhysical Review Letters, 2006
- Dynamics of Polymer Translocation through Nanopores: Theory Meets ExperimentPhysical Review Letters, 2006
- Polymer translocation through a nanopore: A two-dimensional Monte Carlo studyThe Journal of Chemical Physics, 2006
- Polymer translocation through a nanopore induced by adsorption: Monte Carlo simulation of a coarse-grained modelThe Journal of Chemical Physics, 2004
- Anomalous dynamics of forced translocationPhysical Review E, 2004
- Translocation of a polymer chain across a nanopore: A Brownian dynamics simulation studyThe Journal of Chemical Physics, 2003
- Unzipping Kinetics of Double-Stranded DNA in a NanoporePhysical Review Letters, 2003
- Microsecond Time-Scale Discrimination Among Polycytidylic Acid, Polyadenylic Acid, and Polyuridylic Acid as Homopolymers or as Segments Within Single RNA MoleculesBiophysical Journal, 1999
- Polymer Translocation through a Pore in a MembranePhysical Review Letters, 1996