Graft failure IV. Immunologic mechanisms of corneal transplant rejection
Authors:
- 2 August 2007
- journal article
- review article
- Published by Springer Nature in International Ophthalmology
- Vol. 28 (3) , 209-222
Abstract
Corneal transplantation is the oldest and the most common form of solid tissue transplantation in humans. Immunologic graft rejection is one of the main causes of short and long-term graft failure. Rejection involves donor tissue recognition and destruction by allo-specific immune cells of the recipient. This review outlines (1) the immunobiology of transplantation, with reference to ocular immune privilege, (2) factors that confer “high-risk” status to a graft and (3) the pathophysiologic mechanisms of corneal transplant rejection.Keywords
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