Acute Premature Constriction of the Ductus Arteriosus after Maternal Self-Medication with Nimesulide
Authors:
- Federico PrefumoFPFederico Prefumo
- Maurizio MarasiniMMMaurizio Marasini
- Pierangela De BiasioPBPierangela De Biasio
- Pier Luigi VenturiniPVPier Luigi Venturini
- 27 May 2008
- journal article
- case report
- Published by S. Karger AG in Fetal Diagnosis and Therapy
- Vol. 24 (1) , 35-38
Abstract
Objective: To describe clinical findings in a case of premature ductal constriction associated with maternal use of nimesulide, a cyclo-oxygenase type-2 inhibitor. Methods: Case report. Results: A mother self-administered nimesulide at 39 weeks of gestation due to lower back pain. Less than 24 h later premature ductal constriction was diagnosed by echocardiography following a suspicious fetal heart rate recording with baseline tachycardia and absent accelerations. Conclusion: In a term pregnancy, nimesulide administration can rapidly cause premature ductal constriction. This condition may induce abnormalities in the fetal heart rate trace.Keywords
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