Integrating Data into Referral Management Systems: A Global Review and Proposal for Enhanced Specialized Care Regulation

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Abstract
The regulation of access to specialized care represents a persistent challenge within health systems, particularly in countries characterized by significant population and territorial heterogeneity, such as Brazil. This study aimed to analyze, through an integrative literature review, how different countries structure their regulatory systems with a focus on the integration of epidemiological, demographic, and mortality data. The methodology involved a systematic search in the PubMed and Scopus databases, resulting in the selection of 178 articles published between 2015 and 2025. The findings reveal a growing interest in digital and interoperable solutions, with particular emphasis on artificial intelligence, real-time surveillance, and data-driven triage systems. It was observed that governance models vary across countries; however, there is a consensus on the need for systemic integration to promote equity and efficiency. It is concluded that the improvement of systems such as SISREG requires the adoption of international best practices, focusing on interoperable infrastructure, intelligent prioritization, and collaborative governance, to achieve more effective regulation within the context of the Brazilian Unified Health System (SUS).

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