Blood coagulation factor X: molecular biology, inherited disease, and engineered therapeutics
- 22 April 2021
- journal article
- research article
- Published by Springer Nature in Journal of Thrombosis and Thrombolysis
- Vol. 52 (2) , 383-390
Abstract
Blood coagulation factor X/Xa sits at a pivotal point in the coagulation cascade and has a role in each of the three major pathways (intrinsic, extrinsic and the common pathway). Due to this central position, it is an attractive therapeutic target to either enhance or dampen thrombin generation. In this brief review, I will summarize key developments in the molecular understanding of this critical clotting factor and discuss the molecular basis of FX deficiency, highlight difficulties in expressing recombinant factor X, and detail two factor X variants evaluated clinically.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (U54 HL142012, Project 4, P01 HL139420, Project 2)
This publication has 67 references indexed in Scilit:
- Apixaban for Extended Treatment of Venous ThromboembolismNew England Journal of Medicine, 2013
- Rivaroxaban for Thromboprophylaxis in Acutely Ill Medical PatientsNew England Journal of Medicine, 2013
- Zymogen-like factor Xa variants restore thrombin generation and effectively bypass the intrinsic pathway in vitroBlood, 2011
- The Conformational Switch from the Factor X Zymogen to Protease State Mediates Exosite Expression and Prothrombinase AssemblyJournal of Biological Chemistry, 2008
- Structure of Human Des(1-45) Factor Xa at 2·2 Å ResolutionJournal of Molecular Biology, 1993
- Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor XGene, 1991
- Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein CBiochemistry, 1986
- The transition of bovine trypsinogen to a trypsin-like state upon strong ligand bindingJournal of Molecular Biology, 1979
- The transition of bovine trypsinogen to a trypsin-like state upon strong ligand bindingJournal of Molecular Biology, 1978
- Bovine factor X1a (activated Stuart factor). Evidence of homology with mammalian serine proteasesBiochemistry, 1972