The unsaturated cyclitol part of the new antibiotics, the validamycins

Authors:
  • YKYukihiko Kameda
    Yukihiko Kameda
  • SHSatoshi Horii
    Satoshi Horii
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Abstract
Microbial degradation of validamycin A gave a new unsaturated aminocyclitol (5) with the 1S-configuration, establishing the structure (1) of the unsaturated cyclitol portion of validamycin A; the structure of epivalidamine (6), a new aminocyclitol derived from dihydrovalidamycin A was also elucidated.