AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice

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Abstract
West Nile virus (WNV) is transmitted by mosquitoes and can cause severe disease, including meningoencephalitis. AgBR1 is a mosquito salivary protein that enhances Aedes aegypti mosquito-borne Zika virus pathogenesis in mice. Here, we show that AgBR1 antibodies reduce the initial West Nile viral load and delay lethal infection after feeding by an infected Aedes aegypti mosquito. Targeting AgBR1 may therefore be incorporated into strategies to prevent mosquito-transmitted West Nile virus infection.
Funding Information
  • Howard Hughes Medical Institute
  • U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (AI145779, AI127865, AI08992)
  • Japan Society for the Promotion of Science Overseas Research Fellowships

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