Norfloxacin penetration into human renal and prostatic tissues
Authors:
- M G BergeronMBM G Bergeron
- M ThabetMTM Thabet
- R RoyRRR Roy
- C LessardCLC Lessard
- P FoucaultPFP Foucault
Open Access
- 1 August 1985
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 28 (2) , 349-350
Abstract
Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined in 14 patients. Mean ratios of norfloxacin concentration in tissue over concentration in serum were 6.6 +/- 2.8 for the kidney and 1.7 +/- 0.2 for the prostate samples. The levels were above the MICs of most urinary pathogens.Keywords
This publication has 11 references indexed in Scilit:
- Norfloxacin versus trimethoprim-sulfamethoxazole in the therapy of uncomplicated, community-acquired urinary tract infectionsAntimicrobial Agents and Chemotherapy, 1985
- Multiclinic comparative study of norfloxacin and trimethoprim-sulfamethoxazole for treatment of urinary tract infectionsAntimicrobial Agents and Chemotherapy, 1985
- Norfloxacin: activity against urinary tract pathogens and factors influencing the emergence of resistanceJournal of Antimicrobial Chemotherapy, 1984
- The pharmacokinetics and tissue penetration of norfloxacinJournal of Antimicrobial Chemotherapy, 1984
- Bioassay procedures for norfloxacinEuropean Journal of Clinical Microbiology & Infectious Diseases, 1983
- Norfioxacin (MK–0366) treatment of urinary tract infections in hospitalized patientsJournal of Antimicrobial Chemotherapy, 1983
- Norfloxacin disposition after sequentially increasing oral dosesAntimicrobial Agents and Chemotherapy, 1983
- Antibacterial activity of norfloxacinAntimicrobial Agents and Chemotherapy, 1983
- In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprimAntimicrobial Agents and Chemotherapy, 1982
- Influence of Single or Multiple Doses of Gentamicin and Netilmicin on Their Cortical, Medullary, and Papillary DistributionAntimicrobial Agents and Chemotherapy, 1979