The relationship of serum anticholinergic activity to mental status performance in an elderly nursing home population
Authors:
- G D TollefsonGTG D Tollefson
- J Montague-ClouseJMJ Montague-Clouse
- S P LancasterSLS P Lancaster
- 1 August 1991
- journal article
- clinical trial
- Published by American Psychiatric Association Publishing in The Journal of Neuropsychiatry and Clinical Neurosciences
- Vol. 3 (3) , 314-319
Abstract
Adverse drug reactions among elderly patients pose a significant clinical problem. The authors used a serum radioreceptor assay [RRA] to quantify drug-induced muscarinic blockade in 34 randomly selected nursing home residents. A random intervention group and the nonintervention control subjects were then retested 4 weeks later. The reduction of serum antimuscarinic activity (as determined by RRA) did relate to changes on several measures of cognitive function. A calculated "antimuscarinic index" lost significance with the RRA following intervention and may have overestimated the impact of a dosage reduction.Keywords
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