International Validation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) TNM Staging System in Patients With Resected Pancreatic Cancer

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Abstract
Over the past decades, the American Joint Committee on Cancer (AJCC) has established a well-defined system for cancer staging based on 3 key components: local tumor extent (T stage), dissemination to the regional lymph nodes (N stage), and metastatic spread to distant sites (M stage) (TNM staging).1 The AJCC TNM staging system attempts to use anatomical and reproducible parameters to discriminate groups with different survival outcomes.1-4 Reliable prediction of survival estimates is of paramount importance in cancer care. Accurate prognostication helps clinicians in guiding treatment decisions, provides researchers with a tool to adjust for cancer stage in evaluating treatment outcomes, and is informative to patients themselves.5,6

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