The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations

This publication has 51 references indexed in Scilit:

• Assessing the lipophilicity of fragments and early hits
  Journal of Computer-Aided Molecular Design, 2011
• Ligand Efficiency Indices (LEIs): More than a Simple Efficiency Yardstick
  Molecular Informatics, 2011
• Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation
  Drug Discovery Today, 2010
• Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
  Journal of Medicinal Chemistry, 2009
• Simple Size-Independent Measure of Ligand Efficiency
  Journal of Chemical Information and Modeling, 2009
• Two ‘Golden Ratio’ indices in fragment-based drug discovery
  Drug Discovery Today, 2009
• The influence of drug-like concepts on decision-making in medicinal chemistry
  Nature Reviews Drug Discovery, 2007
• The role of molecular size in ligand efficiency
  Bioorganic & Medicinal Chemistry Letters, 2007
• Ligand efficiency indices for effective drug discovery
  Expert Opinion on Drug Discovery, 2007
• Ligand efficiency: a useful metric for lead selection
  Drug Discovery Today, 2004