Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli
Authors:
- J F Garcia-BustosJGJ F Garcia-Bustos
- N PezziNPN Pezzi
- E MendezEME Mendez
- 1 May 1985
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 27 (5) , 791-797
Abstract
Microcin 7 is a small peptide produced and excreted to the culture medium by stationary-phase Escherichia coli cells harboring the pMccC7 plasmid (formerly named pRYC7). This peptide inhibited the growth of the enterobacteria phylogenetically closer to E. coli, apparently by blocking protein biosynthesis. The molecule was degraded with trypsin, and the resulting fragments were purified and sequenced. The results show that microcin 7 is a linear heptapeptide blocked at both ends.Keywords
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