Experimental infection with Plasmodium falciparum does not result in the induction of anticardiolipin antibodies in healthy volunteers
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Open Access
- 1 December 2005
- journal article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 64 (12) , 1804-1805
Abstract
Anopheles stephensi mosquitoes were infected with the chloroquine sensitive NF54 isolate of P falciparum at the insectary, as previously described.5 Sets of female mosquitoes were allowed to feed on the forearms for 10 minutes. Subsequent dissection was performed to confirm the presence of sporozoites in the mosquito salivary glands. If not present, the feed was repeated until successful. Volunteers were carefully monitored by assessing blood films twice daily. Upon microscopic detection of parasites, volunteers were immediately treated with a standard curative regimen of chloroquine.Keywords
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