Synthesis and Antifungal Activities of Some New 5,7‐Disubstituted[1,2,4]Triazolo[1,5‐a]Pyrimidin‐6‐one Derivatives
- 4 September 2015
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 53 (6) , 2079-2083
Abstract
Synthesis of a new series of [1,2,4]triazolo[1,5‐a]pyrimidin‐6‐one by [4 + 2]cycloaddition reaction of 3‐benzylidineamino[1,2,4]triazole with monophenyl ketene and diphenyl ketene generated in situ from phenylacetyl chloride and diphenylacetyl chloride in the presence of triethylamine is described. The newly synthesized compounds were also tested for antifungal activities against Rhizoctonia solani and Trichoderma sp.Keywords
Funding Information
- University Grants Commission (F.5-234/2011-12/MRP/NERO/10757)
This publication has 8 references indexed in Scilit:
- Synthesis and antimicrobial activity of some novel substituted 1,2,4‐triazoles bearing 1,3,4‐oxadiazoles or pyrazolesJournal of Heterocyclic Chemistry, 2011
- 1H NMR, 13C NMR and mass spectral studies of some Schiff bases derived from 3-amino-1,2,4-triazoleSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2009
- Cycloaddition Reaction: Synthesis of 5-Substituted 1,3,4-Thiadiazolo[3,2-a]pyrimidin-6-oneJournal of Chemical Research, 1999
- Syntheses and reactions of [1,3,4]thiadiazolo[3,2‐a]pyrimidinone derivativesJournal of Heterocyclic Chemistry, 1991
- Preparation of triazolo[1,5-c]pyrimidines as potential antiasthma agentsJournal of Medicinal Chemistry, 1990
- Synthesis of 3-Carboethixy-4-oxo-4H-pyrimido[1',2':1,5][1,2,4]triazolo[3,4-b]benzoxazole and 5H-Pyrido[3",2":5',6']pyrimido[1',2':1,5][1,2,4]triazolo[3,4-b]benzoxazole-5-one: Novel HeterocyclesHETEROCYCLES, 1989
- On Triazoles. XIII. The reaction of 5‐benzalimino‐1,2,4‐triazoles with substituted acetyl chloridesJournal of Heterocyclic Chemistry, 1988
- 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agentsJournal of Medicinal Chemistry, 1982