Deciphering competing reaction pathways in the α-C–H functionalization of unprotected alicyclic amines via ketone-mediated hydride transfer
Open Access
- 10 November 2026
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic Chemistry Frontiers
- Vol. 13 (22) , 8011-8022
Abstract
Mechanistic studies establish that ketone-mediated α-C–H functionalization of unprotected alicyclic amines proceeds via concerted hydride transfer from monomeric lithium amides, in competition with N -addition to the oxidant.Keywords
Funding Information
- National Institute of General Medical Sciences (R35GM149246)
- National Institute of General Medical Sciences (R35 GM145320)
- National Institutes of Health (S10OD021758-01A1)
- National Institutes of Health (S10OD030250-01A1)
- National Science Foundation (CHE240143)
- National Science Foundation (2138259)
- National Science Foundation (2138286)
- National Science Foundation (2138307)
- National Science Foundation (2137603)
- National Science Foundation (2138296)
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