Activation of human macrophages. Comparison of other cytokines with interferon-gamma.

Authors:
  • CNC F Nathan
    C F Nathan
  • TPT J Prendergast
    T J Prendergast
  • MWM E Wiebe
    M E Wiebe
  • ESE R Stanley
    E R Stanley
  • EPE Platzer
    E Platzer
  • HRH G Remold
    H G Remold
  • KWK Welte
    K Welte
  • BRB Y Rubin
    B Y Rubin
  • HMH W Murray
    H W Murray
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Abstract
Cytokines affecting mononuclear phagocytes were screened for activation of human macrophages to secrete H2O2 and kill toxoplasmas. In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon-alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. Partially purified migration inhibitory factor (MIF) enhanced H2O2-releasing capacity submaximally without inducing antitoxoplasma activity, and warrants further study.

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