Study of Visceral Adiposity Index and Free Androgen Index in Indian Women With PCOS: A Cross‐Sectional Study

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Abstract
Objective: PCOS is a complex endocrine disorder associated with metabolic and hormonal dysregulation. The visceral adiposity index (VAI) and free androgen index (FAI) have emerged as predictive markers for PCOS. This study aims to evaluate the role of VAI and FAI from the aspect of metabolic and hormonal imbalance in PCOS women from urban and rural areas of India. Study Design and Subjects: Women within the reproductive age of 18–40 years from both rural and urban areas of India were recruited in the study between November 2018 and July 2022 for this cross‐sectional study. 12,100 women were approached to participate in the study, of whom 8993 subjects were enroled. After clinical examination and all investigations according to the protocol, 795 were PCOS cases, while 2475 were non‐PCOS cases as per Rotterdam criteria. The PCOS group was segregated according to obesity. Measurements: Hormonal profile and ovarian morphology were evaluated along with anthropometric parameters. VAI, FAI, and Lipid Accumulation Product (LAP) were calculated based on biochemical parameters. Results: VAI and FAI were significantly elevated in PCOS compared to non‐PCOS. VAI, FAI, and LAP were significantly increased in obese PCOS. VAI, independent of BMI, was significantly associated with the Ferriman Gallaway (FG) score, FBG, fasting insulin, and LAP, whereas FAI was associated with BMI and LAP. Conclusion: The study underscores that VAI may serve as the surrogate marker of PCOS, independent of obesity.
Funding Information
  • Indian Council of Medical Research (5/7/1337/2015‐RBMH Dt. 31/07/2018)

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