Molecular cloning of a cDNA encoding human antihaemophilic factor
Authors:
- John J. TooleJTJohn J. Toole
- John L. KnopfJKJohn L. Knopf
- John M. WozneyJWJohn M. Wozney
- Lisa A. SultzmanLSLisa A. Sultzman
- Janet L. BueckerJBJanet L. Buecker
- Debra D. PittmanDPDebra D. Pittman
- Randal J. KaufmanRKRandal J. Kaufman
- Eugene BrownEBEugene Brown
- Charles ShoemakerCSCharles Shoemaker
- Elizabeth C. OrrEOElizabeth C. Orr
- Godfrey W. AmphlettGAGodfrey W. Amphlett
- W. Barry FosterWFW. Barry Foster
- 1 November 1984
- journal article
- Published by Springer Nature in Nature
- Vol. 312 (5992) , 342-347
Abstract
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.Keywords
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