Polycystic ovary syndrome current status and future perspective
Authors:
- 1 January 2014
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Elite
- Vol. E6 (1) , 104-119
Abstract
Polycystic ovary syndrome (PCOS) is a widespread reproductive disorder that encompasses many associated health conditions and has an impact on various metabolic processes. PCOS is depicted by hyperandrogenism, polycystic ovaries, and anovulation. It increases the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. The etiology of the disease remains unclear, and the subjective phenotype makes a united diagnosis difficult among physicians. It seems to be a familial genetic syndrome caused by a combination of environmental and genetic factors. It can be linked with metabolic disorders in first-degree family members. PCOS is the cause of up to 30% of infertility in couples seeking treatment. Currently, there is no cure for PCOS. Despite the growing incidence of this syndrome, limited research has been done that encompasses the entirety of PCOS spectrum. In this review, the current status and possible future perspective will be discussed.Keywords
This publication has 164 references indexed in Scilit:
- Managing anovulatory infertility and polycystic ovary syndromeBMJ, 2007
- Cancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioner's oral contraception studyBMJ, 2007
- Obesity and Sex Steroid Changes across Puberty: Evidence for Marked Hyperandrogenemia in Pre- and Early Pubertal Obese GirlsThe Journal of Clinical Endocrinology & Metabolism, 2006
- Oral contraceptive use and cancer. Findings in a large cohort study, 1968–2004British Journal of Cancer, 2006
- Ovarian theca cellThe International Journal of Biochemistry & Cell Biology, 2005
- Ultrasound assessment of the polycystic ovary: international consensus definitionsHuman Reproduction Update, 2003
- Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cyclesObstetrics & Gynecology, 2003
- Alternative activation of macrophagesNature Reviews Immunology, 2003
- Coronary Heart Disease Risk Factors in Women With Polycystic Ovary SyndromeArteriosclerosis, Thrombosis, and Vascular Biology, 1995
- Ovarian electrocautery in the treatment of women with polycystii ovary syndrome (PCOS): Factors affecting the resultsActa Obstetricia et Gynecologica Scandinavica, 1994