Effects of Chinese gallnut tannic acid on growth performance, blood parameters, antioxidative status, intestinal histomorphology, and cecal microbial shedding in broilers challenged with aflatoxin B1

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Abstract
The objective of the present study was to investigate the effects of tannic acid (TA) on growth performance, blood parameters, antioxidant capacity, and intestinal health in broilers challenged with aflatoxin B1 (AFB1). A total of 480 1-d-old broilers were randomly allotted into 4 treatments: 1) CON, control diet, 2) AF, CON + 60 μg/kg AFB1 of feed during d 1 to 21, CON + 120 μg/kg AFB1 of feed during d 22 to 42, 3) TA1, AF +250 mg/kg TA, 4) TA2, AF +500 mg/kg TA. Average daily gain (ADG) and average daily feed intake (ADFI) were increased in the TA1 during d 1 to 21, d 22 to 42 and d1 to 42 compared with CON and AF treatments (P < 0.05). Broilers fed the TA2 diet had greater ADG and ADFI than those fed the CON and AF diets during the finisher and the whole period (P < 0.05). Administration of TA decreased the relative weight of liver and kidney compared with broilers fed the AF diet on d 42 (P < 0.05). The blood activity of alanine transferase (ALT) and gamma-glutamyl transferase (GGT) was increased in the AF treatment compared with the CON (P < 0.05). Broilers fed the TA1 decreased the ALT content on d 21, and the level of ALT and GGT was decreased in the TA2 compared with the AF group on d 42 (P < 0.05). The activity of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) in plasma, and the hepatic glutathione S-transferase (GST) was decreased in the AF group compared with the CON group (P < 0.05). The TA decreased plasma malondialdehyde concentration, and increased plasma T-SOD, GSH-Px, total antioxidant capacity, and hepatic GST activity compared to the AF (P < 0.05). The crypt depth of jejunum was decreased in the TA1 treatment on d 21, and the villus height of ileum was increased in the TA2 group on d 42 compared with the AF treatment (P < 0.05). The cecal Lactobacillus counts on d 21 was tended to increase in the TA treatments compared with the AF (P = 0.061). In conclusion, dietary inclusion of 250 mg/kg and 500 mg/kg TA could improve the growth, antioxidant capacity, and partially protected the intestinal health of broilers challenged with AFB1.

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