Low platelet counts and low CD4/CD8 ratios at apheresis increase the risk of CAR T-cell manufacturing failure in myeloma
Authors:
- Tomoyasu JoTJTomoyasu Jo
- Kyoko YoshiharaKYKyoko Yoshihara
- Masaki RiMRMasaki Ri
- Nobuhiro TsukadaNTNobuhiro Tsukada
- Naoya MimuraNMNaoya Mimura
- Keiko FujiiKFKeiko Fujii
- Kentaro FukushimaKFKentaro Fukushima
- Shin-Ichiro FujiwaraSFShin-Ichiro Fujiwara
- Yuji ShimuraYSYuji Shimura
- Kyoko HaraguchiKHKyoko Haraguchi
- Koji KatoKKKoji Kato
- Atsushi SatakeASAtsushi Satake
Open Access
- 24 October 2024
- journal article
- Published by Elsevier in Blood Neoplasia
- Vol. 2 (1)
Abstract
No abstract availableKeywords
Funding Information
- Lotte Foundation
This publication has 20 references indexed in Scilit:
- Risk factors for CAR‐T cell manufacturing failure among DLBCL patients: A nationwide survey in JapanBritish Journal of Haematology, 2023
- Allogeneic BCMA-targeting CAR T cells in relapsed/refractory multiple myeloma: phase 1 UNIVERSAL trial interim resultsNature Medicine, 2023
- Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase InhibitorsCancer Research Communications, 2022
- Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label studyThe Lancet, 2021
- Idecabtagene Vicleucel in Relapsed and Refractory Multiple MyelomaNew England Journal of Medicine, 2021
- Wishing on a CAR: Understanding the Scope of Intrinsic T-cell Deficits in Patients with CancerCancer Discovery, 2019
- International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myelomaThe Lancet Oncology, 2016
- CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patientsJournal of Clinical Investigation, 2016
- Early memory phenotypes drive T cell proliferation in patients with pediatric malignanciesScience Translational Medicine, 2016
- Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivoLeukemia, 2015