DOCKING OF INDOLIZINE DERIVATIVES ON CUBE RHOMBELLANE FUNCTIONALIZED HOMEOMORPHS

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Abstract
Indolizines represent a class of heteroaromatic compounds (of pharmacological importance) containing two condensed (5- and 6-memebered) rings bridged by a nitrogen atom, showing a variety of biological activities. An attempt was made to deposit indolizines on the cube rhombellane homeomorphs surface as possible nano-drug complexes, since rhombellane homeomorphs may be bound in a protein as the active pocket and further may be used in personalized medicine. In the present study, a molecular docking analysis of two indolizine derivatives on some cube rhombellane homeomorphs was carried out for the first time.