Synthesis and DNA-binding properties of polyamine analogs

Authors:
  • RSRonald D. Snyder
    Ronald D. Snyder
  • DSDavid M. Stemerick
    David M. Stemerick
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Abstract
The synthesis of a series of novel polyamine analogues is reported. The DNA binding of these compounds and a variety of other polyamines were compared with their IC50 values against HeLa cell. There seemed to be no apparent correlation between the DNA binding and toxicity against HeLa cells.